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Signet ring cell carcinoma in hyperplastic polyp

W L Zea-Iriarte1, M Itsuno, K Makiyama

  • 1Second Dept. of Internal Medicine, Nagasaki University School of Medicine, Japan.

Scandinavian Journal of Gastroenterology
|June 1, 1995
PubMed
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A gastric hyperplastic polyp in a 68-year-old woman contained a focal signet ring cell carcinoma. This cancer shared mucin characteristics with the surrounding hyperplastic foveolar epithelium.

Area of Science:

  • Gastroenterology
  • Oncology
  • Pathology

Background:

  • A 68-year-old woman underwent polypectomy for three gastric hyperplastic polyps.
  • A focal signet ring cell carcinoma was identified within a 2.2 cm antral gastric hyperplastic polyp.

Observation:

  • The carcinoma was confined to the gastric mucosa.
  • Intestinal metaplasia was minimal.
  • The neoplasm exhibited a predominance of neutral and foveolar mucins over acid mucins.

Findings:

  • Special mucin histochemical stainings were employed to analyze the carcinoma's phenotype.
  • The neoplastic cells showed predominant neutral and foveolar mucin expression.
  • Positive neutral mucin staining was observed in the adjacent hyperplastic foveolar epithelium, while intestinal metaplasia foci stained positive for acid mucin.

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Implications:

  • The gastric carcinoma demonstrated a mixed mucin composition.
  • Histochemical findings suggest shared characteristics between the neoplasm and the surrounding hyperplastic foveolar epithelium.
  • This case highlights the importance of detailed mucin analysis in gastric polyps for accurate diagnosis and understanding of tumorigenesis.