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Updated: Aug 11, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

[Antithrombotic therapy in cerebrovascular disorders]

T Dahl1, U Abildgaard

  • 1Medisinsk avdeling Aker sykehus, Oslo.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|September 30, 1995
PubMed

Insights

Warfarin is recommended for primary and secondary prevention of thromboembolism in patients with non-valvular atrial fibrillation over 60 or with risk factors. Aspirin is an alternative for those with contraindications.

Area of Science:

  • Neurology
  • Cardiology
  • Pharmacology

Context:

  • Guideline recommendations for stroke prevention.
  • Focus on non-valvular atrial fibrillation (NVAF) and thromboembolic risk.
  • Management of ischemic stroke and transient ischemic attacks (TIAs).

Purpose:

  • To outline prophylactic anticoagulant and antiplatelet therapy guidelines.
  • To define patient populations for warfarin and aspirin use.
  • To address the role of anticoagulation in progressive ischemic stroke and embolism.

Summary:

  • Warfarin is indicated for primary and secondary prophylaxis in NVAF patients >60 years or with risk factors.
  • Aspirin is recommended for patients with contraindications to warfarin.
  • Antiplatelet therapy shows a ~25% reduction in subsequent stroke risk for TIAs and minor strokes, and is likely indicated for acute, stable ischemic stroke.

Impact:

  • Informs clinical practice for stroke prevention strategies.
  • Highlights the importance of tailored anticoagulant and antiplatelet therapy.
  • Provides evidence-based recommendations for managing thromboembolic events in specific patient groups.

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