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Updated: Aug 27, 2026

Functional Evaluation of Biological Neurotoxins in Networked Cultures of Stem Cell-derived Central Nervous System Neurons
Published on: February 5, 2015
Neural cell adhesion molecule (N-CAM) distribution may predict the effect of neurotoxins on the brain
G A Ushakova1, V A Berezin, G G Skibo
1Department of Biophysics and Biochemistry, State University, Dniepropetrovsk, Ukraine.
Abstract:
The neural cell adhesion molecule (N-CAM) is a convenient neurospecific marker for investigating the effects of neurotoxins on cell migration, cell recognition and differentiation of neurons during development. In this report, we discuss the developmental toxicity of valproic acid studied by two different approaches (the immunochemical detection of N-CAM content and polypeptide composition, and immunohistochemical analysis of N-CAM topography). Immunohistochemical analysis of distribution of N-CAM as a surface marker on the neural cells predicted the effect of the neurotoxin.
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