Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Postprandial and orthostatic cardiovascular changes after acute stroke

T G Robinson1, J F Potter

  • 1University Division of Medicine for the Elderly, Glenfield Hospital, Leicester, UK.

Stroke
|October 1, 1995
PubMed
Summary

Acute stroke patients do not experience significant post-meal blood pressure drops compared to controls. However, stroke survivors show altered pulse rate responses, indicating potential sympathetic nervous system changes, though meal effects on orthostatic blood pressure control are minimal.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Automated estimation of the logistic curve model of cerebral CO<sub>2</sub> vasomotor reactivity.

Journal of clinical monitoring and computing·2026
Same author

Bridging the age gap in breast cancer: cluster randomized trial of two decision support interventions for older women with operable breast cancer on quality of life, survival, decision quality, and treatment choices.

The British journal of surgery·2021
Same author

INFOMATAS multi-center systematic review and meta-analysis individual patient data of dynamic cerebral autoregulation in ischemic stroke.

International journal of stroke : official journal of the International Stroke Society·2020
Same author

Estimated glomerular filtration rate and risk of poor outcomes after stroke.

European journal of neurology·2019
Same author

Inter-subject analysis of transfer function coherence in studies of dynamic cerebral autoregulation.

Physiological measurement·2018
Same author

Sex differences in cerebral haemodynamics across the physiological range of PaCO<sub>2</sub>.

Physiological measurement·2018

Area of Science:

  • Cardiovascular Physiology
  • Neurology
  • Gerontology

Background:

  • Postprandial hypotension (large blood pressure drops after meals) is observed in elderly individuals and may increase stroke risk.
  • Impaired baroreflex and cerebral autoregulation after acute stroke can exacerbate postprandial blood pressure (BP) changes, potentially worsening stroke progression.

Purpose of the Study:

  • To investigate postprandial hemodynamic responses to orthostasis in acute stroke subjects compared to healthy controls.
  • To examine the impact of an oral energy load on blood pressure, pulse rate, and forearm blood flow in both groups.

Main Methods:

  • A randomized, double-blind, crossover trial involving nine acute stroke subjects and eight age-, sex-, and BP-matched controls.
  • Administration of oral glucose or xylose, with measurements of BP, pulse rate, and forearm blood flow for 120 minutes.

Related Experiment Videos

  • Assessment of hemodynamic responses to 60-degree tilt at baseline and postprandially.

    • Main Results:

    • Control subjects showed significant supine BP falls after glucose, unlike stroke subjects. Stroke subjects exhibited a supine pulse rate increase post-glucose.
    • Stroke subjects displayed impaired orthostatic BP control, with greater mean arterial pressure falls during tilt compared to controls, both pre- and postprandially.
    • No significant differences in forearm vascular resistance were noted; xylose and glucose phases yielded similar results regarding orthostatic responses.

    Conclusions:

    • Acute stroke subjects do not face a higher risk of post-meal BP falls than controls.
    • Stroke survivors exhibit an increased postprandial pulse rate, suggesting heightened sympathetic activity, but meal intake does not affect orthostatic BP control impairment.
    • Orthostatic intolerance is present after acute stroke, but its severity is not exacerbated by meals.