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Related Experiment Videos

Prolactin secretion by metoclopramide in man

S J Judd, L Lazarus, G Smythe

    The Journal of Clinical Endocrinology and Metabolism
    |August 1, 1976
    PubMed
    Summary

    Metoclopramide effectively stimulates prolactin release in both men and women. This potent prolactin stimulus is safe and offers a useful alternative to other medications.

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    Area of Science:

    • Endocrinology
    • Pharmacology

    Background:

    • Prolactin is a key hormone with diverse physiological roles.
    • Identifying reliable stimuli for prolactin secretion is crucial for research and clinical applications.

    Purpose of the Study:

    • To evaluate metoclopramide as a stimulus for prolactin release.
    • To compare metoclopramide's prolactin-releasing effect with thyrotropin-releasing hormone (TRH).

    Main Methods:

    • Intravenous administration of 2.5 mg metoclopramide to 15 participants (6 men, 9 women).
    • Measurement of serum prolactin levels post-administration.
    • Comparison with TRH response in men and assessment of L-dopa's effect on metoclopramide response.

    Main Results:

    • Metoclopramide caused a significant increase in serum prolactin, higher in women than men.
    • Metoclopramide's prolactin response was greater than TRH's response in men.
    • L-dopa pretreatment suppressed the prolactin response to metoclopramide.

    Conclusions:

    • Metoclopramide is a safe, potent, and reliable stimulus for prolactin secretion.
    • Metoclopramide likely acts by blocking hypothalamic dopamine receptors, reducing prolactin inhibiting factor.
    • Metoclopramide presents a viable alternative to chlorpromazine for prolactin stimulation.

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