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Radiation-induced primary brain lymphoma: a case report
M E Stein1, N Haim, M Ben-Shachar
1Chemotherapy Unit, Northern Israel Oncology Center, Haifa, Israel.
Tumori
|May 1, 1995
Summary
Radiation therapy for glioma may increase the risk of developing secondary primary brain lymphoma years later. Aggressive chemotherapy, including high-dose methotrexate, showed prompt effectiveness in this case.
Area of Science:
- Neuro-oncology
- Radiation oncology
- Hematology
Background:
- Primary brain lymphoma is a rare malignancy.
- Secondary malignancies can arise after cancer treatment.
- Whole brain irradiation is a known risk factor for certain secondary cancers.
Observation:
- A patient developed primary brain lymphoma 6 years after whole brain irradiation for a low-grade glioma.
- The patient had no signs of immunodeficiency.
- The lymphoma responded well to chemotherapy.
Findings:
- The timing, latency, and histology suggest radiation-induced primary brain lymphoma.
- High-dose methotrexate was a key component of the effective chemotherapy regimen.
- This case highlights a potential long-term complication of brain radiation therapy.
Implications:
- Consider radiation-induced secondary primary brain lymphoma in patients with a history of cranial irradiation.
- Aggressive chemotherapy regimens, particularly high-dose methotrexate, are effective treatments.
- Further research is needed to understand the mechanisms and incidence of radiation-associated brain lymphomas.