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Evaluation of asymptomatic microhematuria
J A Fracchia1, J Motta, L S Miller
1Division of Urology, Lenox Hill Hospital, New York, New York 10021, USA.
Urology
|October 1, 1995
Summary
A new urine test helps pinpoint the cause of asymptomatic microhematuria by analyzing urine cells. This cytodiagnostic assay aids in differentiating between urologic and renal bleeding sources.
Area of Science:
- Urology
- Nephrology
- Diagnostic Assays
Background:
- Asymptomatic microhematuria evaluation requires accurate localization of bleeding source.
- Routine urologic evaluation may not always distinguish between renal and urologic etiologies.
Purpose of the Study:
- To assess a comprehensive urine cytodiagnostic assay for localizing the origin and cause of asymptomatic microhematuria.
- To compare the assay's performance against standard urologic evaluations.
Main Methods:
- One hundred patients with asymptomatic microhematuria underwent routine urologic evaluation and a refined urine cytodiagnostic assay.
- Significant findings were defined as calculi and neoplasms.
Main Results:
- The assay identified urothelial bladder neoplasms and most urinary calculi.
- Dysmorphic red blood cells (RBCs) and RBC casts indicated renal bleeding, with 98% of these patients lacking significant urologic findings.
- Significant urologic disease incidence was 13%.
Conclusions:
- The refined urine cytodiagnostic assay shows promise in differentiating urologic from renal causes of microhematuria.
- This specialized urinalysis may enhance diagnostic yield in patients with asymptomatic microhematuria.