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Closantel intoxication in a dog

K McEntee¹, M Grauwels, C Clercx

¹Small Animal Clinic, Department of Internal Medicine, Faculty of Veterinary Medicine, University of Liege, Belgium.

Veterinary and Human Toxicology

|June 1, 1995

Summary

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Closantel overdosage in a dog caused irreversible blindness and other serious health issues. Prompt albumin therapy helped reduce acute toxicity, but some effects were permanent.

Area of Science:

Veterinary Medicine
Toxicology
Pharmacology

Background:

Salicynalide derivatives like closantel are used for antiparasitic treatment in animals.
Accurate dosing is crucial to prevent adverse effects.
This case examines the consequences of a significant closantel overdose in a canine patient.

Observation:

A dog was administered six times the recommended dose of closantel.
The animal exhibited symptoms including optic neuritis, retinal degeneration, partial deafness, liver damage (hepatotoxicosis), and muscle disease (myopathy).

Findings:

The closantel overdose resulted in multiple toxic effects.
While some conditions improved with treatment, blindness was irreversible.
Albumin administration was employed to mitigate the acute toxicity of closantel.

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Implications:

This case highlights the severe risks associated with closantel overdosage in dogs.
It underscores the importance of precise drug administration in veterinary practice.
Understanding these toxic effects can inform treatment protocols for accidental overdoses.