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Ketorolac-induced postoperative acute renal failure: a case report
1Department of Surgery, Gundersen Clinic, La Crosse, WI 54601, USA.
Wisconsin Medical Journal
|January 1, 1995
Summary
Nonsteroidal anti-inflammatory drugs (NSAIDs) can harm kidneys. Even without risk factors, short-term ketorolac use may cause kidney failure, highlighting the need for physician awareness.
Area of Science:
- Nephrology
- Pharmacology
- Clinical Medicine
Background:
- Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain management.
- The nephrotoxic potential of NSAIDs is a known clinical concern.
- Risk factors for NSAID-induced kidney injury include dehydration and pre-existing kidney disease.
Observation:
- A case of acute kidney injury (AKI) is presented following short-term intramuscular ketorolac administration.
- The patient had no prior history of renal disease or other identified risk factors for nephrotoxicity.
- The surgical procedure was an uncomplicated laparotomy.
Findings:
- Intramuscular ketorolac, a potent NSAID, can precipitate renal failure even in individuals without apparent risk factors.
- This case underscores the potential for ketorolac to cause significant kidney damage.
- Review of existing literature confirms ketorolac-induced renal failure as a recognized, albeit potentially underappreciated, complication.
Implications:
- Physicians must maintain a high index of suspicion for ketorolac-induced nephrotoxicity.
- Careful patient selection and monitoring are crucial when prescribing ketorolac, especially post-operatively.
- Awareness of this adverse effect is vital for preventing potentially severe renal complications.