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Related Experiment Videos

Implementing universal vaccination programmes: Bulgaria

N Gatcheva1, N Vladimirova, A Kourtchatova

  • 1Department of Epidemiology, National Centre of Infections and Parasitic Diseases, Sofia, Bulgaria.

Vaccine
|January 1, 1995
PubMed
Summary

Universal vaccination against hepatitis B virus (HBV) in Bulgaria significantly reduced infant infections by 82%. Expanding coverage to all young children is recommended to further decrease the chronic HBV burden.

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Area of Science:

  • Public Health
  • Epidemiology
  • Immunization Programs

Background:

  • Bulgaria implemented universal hepatitis B virus (HBV) vaccination for newborns in August 1991.
  • This followed a three-year selective immunization program for infants born to HBsAg-positive mothers.

Purpose of the Study:

  • To evaluate the impact of universal HBV vaccination on infant morbidity in Bulgaria.
  • To assess the trend of hepatitis B incidence post-vaccination introduction.

Main Methods:

  • Analysis of hepatitis B morbidity data among infants from 1989 to 1992.
  • Calculation of incidence rates and percentage decrease compared to the pre-immunization period.

Main Results:

  • Vaccination coverage reached 71.3% in 1992.

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  • Infant hepatitis B morbidity showed a continuous downward trend, reaching 0.3 cases per 100,000 in 1992.
  • This represents an 82% decrease in incidence compared to the pre-vaccination era.

    • Conclusions:

    • Universal HBV vaccination has been highly effective in reducing infant hepatitis B infections in Bulgaria.
    • Expanding vaccination to all children up to 6 years is proposed to further mitigate the long-term burden of chronic HBV infection.