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Calcitonin gene-related peptide and peripherin immunoreactivity in nerve sheaths
1Department of Cell Biology and Anatomy, University of North Carolina at Chapel Hill 27599, USA.
Somatosensory & Motor Research
|January 1, 1995
Abstract:
The intrinsic innervation of rat sciatic nerve sheaths was studied by means of immunohistochemical labeling for calcitonin gene-related peptide (CGRP) and peripherin. CGRP immunoreactivity (CGRP-IR) and peripherin immunoreactivity (peripherin-IR) were found in fine nerve fibers independent of nerve sheath vasculature. These findings suggest that a subset of the nervi nervorum may have nociceptive functions, and that this subset is distinct from nerve fibers that innervate the blood vessels of the nerve sheaths.