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Related Experiment Videos

Age-related decrease of nerve growth factor-like immunoreactivity in the basal forebrain of senescence-accelerated

K Ohnishi1, H Tomimoto, I Akiguchi

  • 1Department of Neurology, Faculty of Medicine, Kyoto University, Japan.

Acta Neuropathologica
|January 1, 1995
PubMed
Summary

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The senescence-accelerated mouse P10 (SAMP10) model shows age-related decline in nerve growth factor (NGF) in the basal forebrain. This study investigated NGF distribution in SAMP10 mice, revealing decreased levels with aging.

Area of Science:

  • Neuroscience
  • Aging Research
  • Immunohistochemistry

Background:

  • The senescence-accelerated mouse P10 (SAMP10) model exhibits accelerated aging, including cognitive decline.
  • Nerve growth factor (NGF) plays a crucial role in neuronal survival and function.

Purpose of the Study:

  • To investigate the distribution and age-related changes of NGF in the brains of SAMP10 mice and their control strain (SAMR1).

Main Methods:

  • Immunohistochemistry was used to detect NGF-like immunoreactivity (NGF-IR) in neurons and glial cells across different brain regions.
  • Comparison of NGF-IR was made between young (2-month-old) and aged (10-month-old) SAMP10 mice, as well as with SAMR1 controls.

Main Results:

  • NGF-IR was present in forebrain neurons and specific glial cells in both SAMP10 and SAMR1 mice.

Related Experiment Videos

  • Aged SAMP10 mice showed a decreased cortical mantle thickness but retained NGF-IR in cortical layers.
  • A significant age-related decline in NGF-IR was observed in the substantia innominata of 10-month-old SAMP10 mice compared to 2-month-old mice.

    • Conclusions:

    • The study indicates an age-related decrease in NGF levels within the basal forebrain of SAMP10 mice.
    • These findings contribute to understanding the neurobiological underpinnings of accelerated aging and cognitive deterioration in this model.