Related Experiment Video
Updated: Aug 11, 2026

FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
Interstitial duplication 19p
R F Stratton1, B R DuPont, A S Olsen
1South Texas Genetics Center, University of Texas Health Science Center, San Antonio, USA.
Abstract:
We report on a 9-month-old girl with an interstitial duplication of 19p, developmental delay, and multiple anomalies including bifrontal prominence, obtuse frontonasal angle, short columella, additional midline philtral pillar, midline ridge on the tongue, vertical midline ridge at the mental symphysis, and a complex congenital heart defect including severe branch pulmonary artery stenosis, secundum atrial septal defect (ASD), and several ventricular septal defects (VSDs). Use of fluorescent in situ hybridization (FISH) with chromosome 19-specific probes showed a direct duplication of bands 19p13.13 and 19p13.2.
Related Concept Videos
Meiosis I
Karyotyping
Karyotyping
Polytene Chromosomes
Polytene Chromosomes
Chromosome Duplication
The basic unit of the chromatin is the nucleosome, consisting of DNA wrapped around octameric histone proteins and short stretches of linker DNA separating individual nucleosomes. The histone proteins within the nucleosome have their...

