Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Automated linkage analysis in psychiatric disorders

L He1, D C Mansfield, A F Brown

  • 1MRC Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom.

American Journal of Medical Genetics
|June 19, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Canadian Surgery Forum: Abstracts of presentations to the Annual Meetings of the Canadian Association of Bariatric Physicians and Surgeons, Canadian Association of General Surgeons, Canadian Association of Thoracic Surgeons, Canadian Hepato-Pancreato-Biliary Association, Canadian Society of Surgical Oncology, Canadian Society of Colon and Rectal Surgeons, Vancouver, BC, Sept. 17-21, 2013.

Canadian journal of surgery. Journal canadien de chirurgie·2025
Same author

The effect of pre-analytical variables on downstream application and data analysis of human endometrial biopsies.

Human reproduction open·2022
Same author

Canadian Surgery Forum 2018: St. John's, NL Sept. 13-15, 2018.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same author

Canadian Surgery Forum: Abstracts of presentations to the Annual Meetings of the Canadian Association of Bariatric Physicians and Surgeons, Canadian Association of General Surgeons, Canadian Association of Thoracic Surgeons, Canadian Hepato-Pancreato-Biliary Society, Canadian Society of Surgical Oncology, Canadian Society of Colon and Rectal Surgeons, London, Ont. Sept. 15-18, 2011.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same author

2021 Canadian Surgery Forum: Virtual, online Sept. 21-24, 2021.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same author

Phosphate stress triggers the conversion of glycerol into l-carnitine in Pseudomonas fluorescens.

Microbiological research·2021
Same journal

Abstracts for the Xth World Congress of Psychiatric Genetics. Brussels, Belgium, 9-13 October 2002.

American journal of medical genetics·2003
Same journal

Defects of blastogenesis.

American journal of medical genetics·2002
Same journal

Malformations of the craniofacial region: evolutionary, embryonic, genetic, and clinical perspectives.

American journal of medical genetics·2002
Same journal

Limb anomalies: Developmental and evolutionary aspects.

American journal of medical genetics·2002
Same journal

Molecular etiology of gut malformations and diseases.

American journal of medical genetics·2002
Same journal

Status of the human malformation map: 2002.

American journal of medical genetics·2002
See all related articles

Automating linkage analysis speeds up genetic studies for major psychoses. The Automated Linkage Preprocessor (ALP) program enhances accuracy and reduces costs in genetic marker analysis.

Area of Science:

  • Genetics
  • Bioinformatics
  • Psychiatric Genetics

Background:

  • Genome-wide linkage analysis for major psychoses is time-consuming.
  • Automation can improve the speed and efficiency of this process.

Purpose of the Study:

  • To describe the Automated Linkage Preprocessor (ALP) program for analyzing genetic marker data.
  • To demonstrate the utility of ALP in linkage studies for psychiatric disorders.

Main Methods:

  • Utilized the Automated Linkage Preprocessor (ALP) program for computer analysis of fluorescently labeled microsatellite markers.
  • Employed an automated laser fluorescence (ALF) sequencer and Fragment Manager software for PCR product detection and sizing.
  • Generated genotypes suitable for direct input into linkage analysis programs.

Related Experiment Videos

Main Results:

  • The ALP program facilitates the detection and sizing of PCR products.
  • It effectively filters nonallele fluorescent peaks, improving genotype accuracy.
  • The system generates genotypes in a format compatible with standard linkage analysis software.

Conclusions:

  • The described automated method offers increased speed, accuracy, and cost-effectiveness for linkage analysis.
  • This approach is valuable for genetic studies of complex psychiatric disorders like manic-depressive illness.