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Related Experiment Videos

Polystyrene microspheres decrease bronchial artery resistance in anesthetized sheep

D B Pearse1, H E Fessler, E M Wagner

  • 1Division of Pulmonary and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21224, USA.

The American Journal of Physiology
|September 1, 1995
PubMed
Summary
This summary is machine-generated.

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Microspheres used for measuring blood flow can decrease bronchial artery resistance by releasing vasodilators. This effect may overestimate bronchial blood flow if measurements are taken too frequently.

Area of Science:

  • Physiology
  • Cardiovascular Research
  • Pulmonary Medicine

Background:

  • Accurate measurement of tissue blood flow is crucial.
  • Microsphere techniques are widely used but may influence regional hemodynamics.
  • The effect of microspheres on bronchial artery tone requires investigation.

Purpose of the Study:

  • To determine if microspheres alter bronchial artery resistance.
  • To investigate the mechanisms behind any observed changes in bronchial artery tone.

Main Methods:

  • Anesthetized sheep were used with cannulated and perfused bronchial arteries.
  • Varying doses of 15-micron microspheres were infused at constant flow.
  • Pressure-flow relationships were analyzed before and after microsphere infusion.

Related Experiment Videos

  • Pharmacological agents (adenosine-receptor antagonist, cyclooxygenase inhibitor) were used to probe mechanisms.

    • Main Results:

    • Microsphere infusion caused a dose-dependent decrease in bronchial artery pressure, indicating reduced resistance.
    • This reduction in resistance was self-limited, lasting up to 31 minutes.
    • The response was partially attenuated by adenosine-receptor and cyclooxygenase inhibition, suggesting mediator release.
    • Left atrial injection of microspheres also decreased bronchial artery resistance.

    Conclusions:

    • Microspheres can induce vasodilation in the bronchial artery, likely via adenosine and prostaglandin release.
    • Overestimation of bronchial blood flow is possible with repetitive microsphere measurements within 30 minutes.
    • Careful consideration of measurement intervals is necessary when using microspheres for bronchial blood flow assessment.