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Related Experiment Videos

[Biological glue does not reduce lymphorrhoea after lymph node excision. Randomized prospective study on 40 patients]

F Vaxman1, R Kolbe, F Stricher

  • 1Service de Chirurgie Digestive et Générale, Hôpitaux Universitaires de Strasbourg.

Annales De Chirurgie
|January 1, 1995
PubMed
Summary

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Fibrin glue application after axillary lymph node dissection in breast cancer patients did not reduce drainage volume. This method, however, was associated with a higher incidence of complications.

Area of Science:

  • Oncology
  • Surgical Innovation
  • Biomaterials in Surgery

Background:

  • Axillary lymph node dissection (ALND) is a standard procedure for breast cancer staging.
  • Post-operative lymphorrhoea and complications are common after ALND.
  • Fibrin glue has been explored as an adjunct to reduce fluid collection and improve healing.

Purpose of the Study:

  • To evaluate the efficacy of fibrin glue in reducing lymphorrhoea and complications following ALND in breast cancer patients.
  • To compare drainage volume, duration, and complication rates between patients receiving fibrin glue and a control group.

Main Methods:

  • Prospective, randomized study involving 40 female breast cancer patients undergoing ALND.
  • Group A (n=20) received fibrin glue spray in the axillary dissection area.

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  • Group B (n=20) served as the control group.
  • Statistical analysis included Student's t test, Mann and Whitney test, and chi-squared test.

    • Main Results:

    • The fibrin glue group (Group A) showed significantly higher average lymphorrhoea volume (410.4 ml) compared to the control group (275.5 ml, p=0.016).
    • No significant differences were observed in mastectomy/lumpectomy site drainage, total drainage volume, or drainage duration.
    • Complication rates were higher in the fibrin glue group (6 complications) versus the control group (1 complication, p=0.037).

    Conclusions:

    • Fibrin glue application after ALND did not reduce lymphorrhoea and was associated with an increased risk of complications.
    • The use of fibrin glue in this context may not offer therapeutic benefits and could potentially increase adverse events.