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Protection of mice from Mycobacterium avium infection by recombinant interleukin-12
K Kobayashi1, T Kasama, J Yamazaki
1First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.
Antimicrobial Agents and Chemotherapy
|June 1, 1995
Abstract:
Treatment with interleukin-12 (IL-12) significantly reduced the number of viable bacteria in mice infected with Mycobacterium avium. IL-12 itself, however, could not inhibit directly mycobacterial growth in vitro. IL-12 exerts antimycobacterial activity in vivo with a low level of toxicity, possibly by enhancing the host defense against the infection.