[Chronochemotherapy in two cases of metastatic liver cancer]

Chronochemotherapy was performed in two cases of metastatic liver cancer. One was a 51-year-old woman whose pancreas tumor was incompletely removed six months ago and had a residual pancreas tumor (30 x 20 mm2) with liver metastases in S4. Another was a 54-year-old woman whose sigma colon cancer had been removed 10 months ago. A large metastatic tumor in the fourth section of the liver and multiple daughter tumors in other parts of the liver were seen. The hyperthermic chemotherapy using warmed 5% glucose solution administered intraarterially could not be used for these patients. The variable rate of infusion of 5FU (250 mg/body) and CDDP (3.3 mg/body) (23:19:00-7:00) (1/3:7:00-10:00) as chronotherapy showed more efficacy as an anti-cancer treatment compared to their continuous infusion.