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Coeliac disease in children of West Indian origin
J C Hung1, A D Phillips, J A Walker-Smith
1Academic Department of Paediatric Gastroenterology, Queen Elizabeth Hospital for Children, London.
Archives of Disease in Childhood
|August 1, 1995
Insights
Coeliac disease is rare in non-European populations. However, this study highlights two cases in English-born West Indian children, suggesting it should be considered in this demographic presenting with chronic diarrhea.
Area of Science:
- Pediatric Gastroenterology
- Clinical Medicine
- Genetics
Background:
- Coeliac disease (CD) is an immune-mediated enteropathy typically associated with HLA-DQ2/DQ8 genotypes.
- While historically considered uncommon in non-European populations, evolving diagnostic criteria and increased awareness are revealing its presence in diverse ethnic groups.
- Genetic predisposition and environmental triggers, such as gluten exposure, are key factors in CD pathogenesis.
Observation:
- Two cases of coeliac disease are presented in English-born children of West Indian origin.
- Both children presented with chronic diarrhea, a common but non-specific symptom of coeliac disease.
- These cases challenge the traditional understanding of coeliac disease epidemiology.
Findings:
- The diagnosis of coeliac disease should be actively considered in pediatric patients of West Indian ancestry presenting with persistent diarrhea.
- This observation suggests that coeliac disease may be underdiagnosed in this specific ethnic group.
- Further research is warranted to understand the prevalence and potential unique clinical presentations of coeliac disease in West Indian populations.
Implications:
- Clinicians should broaden their differential diagnosis for chronic diarrhea in children of West Indian origin to include coeliac disease.
- Increased awareness and targeted screening may improve early diagnosis and management of coeliac disease in underrepresented populations.
- Understanding the genetic and environmental factors contributing to coeliac disease in diverse ethnicities is crucial for global public health initiatives.
Abstract:
Coeliac disease is uncommon in populations of non-European origin. Two English born West Indian children with coeliac disease are presented. The diagnosis should be considered in children of West Indian origin with chronic diarrhoea.