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Related Experiment Videos

Superficial esophageal carcinoma

J F Sabik1, T W Rice, J R Goldblum

  • 1Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Ohio 44195, USA.

The Annals of Thoracic Surgery
|October 1, 1995
PubMed
Summary

Superficial esophageal carcinoma resection outcomes vary. Early-stage Tis and intramucosal T1 tumors, and those without lymph node metastasis, show better survival in resected superficial esophageal carcinoma. Post-therapy downstaged tumors had similar survival regardless of invasion depth.

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Area of Science:

  • Oncology
  • Gastroenterology
  • Surgical Oncology

Background:

  • Increased detection of superficial esophageal carcinomas via surveillance endoscopy.
  • Downstaging of advanced esophageal carcinomas to superficial types through induction therapy.
  • Growing number of patients undergoing resection for these conditions necessitates understanding outcomes.

Purpose of the Study:

  • Evaluate surgical resection results for superficial esophageal carcinoma.
  • Identify predictors of improved survival in these patients.
  • Analyze outcomes for both primary superficial esophageal carcinoma and downstaged tumors.

Main Methods:

  • Retrospective review of patients with superficial esophageal carcinoma at presentation (SECP).
  • Retrospective review of patients with advanced carcinomas downstaged to superficial types after induction therapy (SECD).

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  • Analysis of survival rates based on tumor stage, invasion depth, and lymph node status.

    • Main Results:

    • For SECP, Tis and intramucosal T1 carcinomas had significantly better 5-year survival (85.3% and 79.4%) than submucosal T1 (16.3%).
    • N0 SECP patients had better 5-year survival (65.2%) than N1 patients (none survived >3 years).
    • For SECD, 4-year survival was 58.2%, unrelated to tumor invasion depth or lymph node status.

    Conclusions:

    • Tis and intramucosal T1 SECP correlate with significantly better survival than submucosal T1 SECP.
    • N0 SECP demonstrates significantly better survival compared to N1 SECP.
    • Survival for SECD patients is not influenced by tumor invasion depth or lymph node status.