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Retroperitoneal sarcomas and their management
C P Karakousis1, R Gerstenbluth, K Kontzoglou
1Department of Surgery, State University of New York at Buffalo, Millard Fillmore Hospital, USA.
Archives of Surgery (Chicago, Ill. : 1960)
|October 1, 1995
Summary
Modern surgical techniques have improved retroperitoneal sarcoma management, achieving a 96% resectability rate. Survival rates, influenced by histologic grade, now rival those of extremity sarcomas, offering new hope for patients.
Area of Science:
- Surgical Oncology
- Sarcoma Research
- Cancer Treatment
Background:
- Retroperitoneal sarcomas pose significant management challenges due to high unresectability rates.
- Historically, these tumors have been difficult to treat effectively.
Purpose of the Study:
- To identify prognostic factors, assess resectability, and evaluate survival outcomes for retroperitoneal sarcoma patients.
- To analyze outcomes in a more recent treatment period.
Main Methods:
- Retrospective review of 90 consecutive patients with retroperitoneal sarcomas treated between 1977 and 1995.
- Mean follow-up of 47 months at a tertiary care cancer institute.
- All patients with localized retroperitoneal sarcoma were included.
Main Results:
- Achieved a 96% overall resectability rate for retroperitoneal sarcomas using modern surgical techniques.
- Reported 5-year survival of 63% and 10-year survival of 46%.
- Wide or radical resection significantly reduced local recurrence rates (16%) compared to local excision (56%) (P < .001).
Conclusions:
- Modern surgical approaches have dramatically increased the resectability of retroperitoneal sarcomas.
- Survival outcomes are significantly influenced by histologic grade and resection margins.
- Survival rates for retroperitoneal sarcomas approach those observed for extremity sarcomas.