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[Growth hormone secretion and nutrition]
G M de Lemos Silva1, J Tirapegui
1Departamento de Alimentos e Nutrição Experimental, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo - USP.
Arquivos De Gastroenterologia
|October 1, 1994
Summary
Growth hormone (GH) stimulates tissue growth indirectly via insulin-like growth factors and directly opposes insulin. Its release is regulated by hypothalamic hormones, influenced by various factors including nutrition.
Area of Science:
- Endocrinology
- Metabolism
- Physiology
Background:
- Growth hormone (GH) is a key endocrine regulator of growth and metabolism.
- GH exerts both direct and indirect effects on tissues and metabolic fuels.
- GH release is controlled by complex hypothalamic mechanisms.
Purpose of the Study:
- To elucidate the multifaceted actions of growth hormone.
- To describe the regulation of growth hormone secretion.
- To highlight the interplay between growth hormone, nutrition, and overall growth.
Main Methods:
- Review of existing literature on growth hormone physiology.
- Analysis of the mechanisms underlying GH action.
- Examination of factors influencing GH release.
Main Results:
- GH promotes skeletal and tissue growth primarily through insulin-like growth factors.
- Direct GH actions are largely insulin-antagonistic, with some acute insulin-like effects.
- GH release depends on the balance of somatostatin and growth hormone-releasing hormone.
Conclusions:
- Growth hormone's effects are complex, involving both direct and indirect pathways.
- GH secretion is modulated by age, sex, hormones, and nutritional status.
- A significant relationship exists between growth hormone, nutrition, and growth processes.