Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Study on Mycobacterium tuberculosis: the primary drug resistance pattern

M A Siddique1, K M Rahman, N Muazzam

  • 1Deptt. of Microbiology, Dhaka Medical College, Bangladesh.

Bangladesh Medical Research Council Bulletin
|April 1, 1995
PubMed
Summary

Primary drug resistance in tuberculosis patients is high, with most M. tuberculosis strains resistant to Streptomycin and Ethambutol. Non-tuberculous mycobacteria showed resistance to common TB drugs.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Breast Cancer Risk Factors and Breast Complaints Among Kenyan Women.

JCO global oncology·2026
Same author

Comparative Study of Complications of Single-Tract versus Multi-Tract Percutaneous Nephrolithotomy Using the Modified Clavien System.

Mymensingh medical journal : MMJ·2025
Same author

Distinctive seizure signature in the first video case-control study of a naturally-occurring feline autoimmune encephalitis model.

Brain, behavior, and immunity·2025
Same author

Relation of Serum Ferritin Level with Severity of Neurological Disability among Patients with Acute Ischemic Stroke.

Mymensingh medical journal : MMJ·2024
Same author

Diagnostic Value of Ultrasonography in Determination of Knee Joint Pathologies with Comparison to MRI.

Mymensingh medical journal : MMJ·2024
Same author

Global Trial Representation and Availability of Tyrosine Kinase Inhibitors for Treatment of Chronic Myeloid Leukemia.

Cancers·2024

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Tuberculosis (TB) remains a significant global health challenge.
  • Drug resistance in Mycobacterium tuberculosis complicates treatment and control efforts.
  • Understanding primary drug resistance patterns is crucial for effective TB management.

Purpose of the Study:

  • To investigate the primary drug resistance patterns of tubercle bacilli.
  • To analyze resistance in both Mycobacterium tuberculosis and non-tuberculous mycobacteria (MOTT) species.
  • To assess resistance to four key anti-tubercular drugs: Isoniazid, Rifampicin, Streptomycin, and Ethambutol.

Main Methods:

  • Sputum samples from 961 suspected TB patients were collected.
  • Ziehl-Neelsen staining identified Acid Fast Bacilli (AFB).

Related Experiment Videos

  • Microscopically positive AFB cases (105) were cultured on Lowenstein-Jensen media, with 91 identified as M. tuberculosis and 9 as MOTT species.

    • Main Results:

    • High sensitivity of M. tuberculosis to Isoniazid (97.80%), Streptomycin (100%), and Ethambutol (100%).
    • Lower sensitivity of M. tuberculosis to Rifampicin (80.21%).
    • MOTT species showed high resistance to Isoniazid and Rifampicin, but sensitivity to Streptomycin (44.44%) and Ethambutol (77.78%).
    • Overall, 27 isolates (18 M. tuberculosis, 9 MOTT) exhibited resistance to at least one drug, with significant multi-drug resistance observed in MOTT species.

    Conclusions:

    • Primary drug resistance in pulmonary tuberculosis patients in Dhaka is a concern.
    • M. tuberculosis strains showed high sensitivity to most tested drugs, except Rifampicin.
    • MOTT species exhibited substantial resistance to Isoniazid and Rifampicin, highlighting the need for accurate species identification and tailored treatment strategies.