Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Drosophila development pulls the strings of the cell cycle

B H Reed1

  • 1Whitehead Institute for Biomedical Research, Cambridge, MA, USA.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|June 1, 1995
PubMed
Summary

String gene transcription precisely controls cell division timing in Drosophila development. This gene acts as a key activator of mitosis, ensuring proper embryonic development patterns.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Downregulation of Jun kinase signaling in the amnioserosa is essential for dorsal closure of the Drosophila embryo.

Current biology : CB·2001
Same author

The hindsight gene is required for epithelial maintenance and differentiation of the tracheal system in Drosophila.

Developmental biology·2000
Same author

The Drosophila gene morula inhibits mitotic functions in the endo cell cycle and the mitotic cell cycle.

Development (Cambridge, England)·1997
See all related articles

Area of Science:

  • Developmental biology
  • Cell cycle regulation
  • Genetics

Background:

  • Cell division in early Drosophila embryogenesis follows a strict pattern.
  • The string gene plays a crucial role in initiating mitosis during this period.

Purpose of the Study:

  • To investigate the regulatory mechanisms controlling string gene transcription.
  • To understand how string influences the timing and pattern of mitosis in Drosophila embryos.

Main Methods:

  • Analysis of string gene transcription in various Drosophila mutants (pattern formation, cell cycle arrest).
  • Characterization of cis-acting regulatory regions associated with the string gene.

Main Results:

  • String gene transcription is essential and sufficient for triggering mitosis in postblastoderm embryos.
  • The string gene product is a positive regulator of cdc2 kinase, homologous to cdc25 phosphatase.
  • Evidence indicates complex developmental control over string transcription.

Conclusions:

  • String gene transcription is tightly regulated during Drosophila embryogenesis.
  • This regulation dictates the precise timing and spatial pattern of cell division.
  • Understanding string's role provides insights into developmental cell cycle control.

Related Experiment Videos