Related Experiment Videos
Ferrochelatase binds the iron-responsive element present in the erythroid 5-aminolevulinate synthase mRNA
1Department of Biochemistry and Molecular Biology, College of Medicine, University of South Florida, Tampa 33612, USA.
Biochemical and Biophysical Research Communications
|September 25, 1995
Abstract:
Ferrochelatase, the terminal enzyme of the heme biosynthetic pathway, binds an iron-responsive element (IRE) present in the 5'untranslated region of the mRNA for erythroid 5-aminolevulinate synthase, the first enzyme of the heme biosynthetic pathway. This IRE-binding activity of ferrochelatase may play a critical role in the regulation of heme biosynthesis in differentiating erythrocytes.