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SPECT abnormalities in generalized dystonia

M S LeDoux1, S L Rutledge, J M Mountz

  • 1Department of Psychology, University of Alabama at Birmingham 35294, USA.

Pediatric Neurology
|July 1, 1995
PubMed
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This study investigated cerebellar function in dystonia using regional cerebral blood flow imaging. Findings suggest the cerebellum may contribute to motor symptoms in some dystonia patients.

Area of Science:

  • Neuroscience
  • Neurology
  • Medical Imaging

Background:

  • Dystonia is a movement disorder characterized by involuntary muscle contractions.
  • The pathophysiology of dystonia is not fully understood, with potential roles for basal ganglia and cortical circuits.
  • Cerebellar involvement in dystonia has been hypothesized but requires further investigation.

Observation:

  • Regional cerebral blood flow (rCBF) was measured using technetium-99m hexamethylpropyleneamine oxime single-photon emission computed tomography (SPECT).
  • A patient with severe, generalized dystonia and 6 controls underwent SPECT imaging.
  • Regions of interest included caudate nuclei, thalami, deep cerebellar nuclei, and cerebellar cortices, normalized to whole-brain rCBF.

Findings:

  • The dystonic patient exhibited interhemispheric asymmetry in deep cerebellar nuclei rCBF.

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  • Increased rCBF was observed in subcortical motor structures in the patient.
  • An abnormal correlation between right cerebellar cortical and right deep cerebellar nuclear rCBF was noted.

    • Implications:

    • These findings provide evidence for abnormal cerebellar function in a patient with dystonia.
    • The cerebellum may play a role in the motor signs observed in some dystonia cases.
    • Further research into cerebellar contributions to dystonia pathophysiology is warranted.