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Genetic mapping and expression analysis of the murine DNA ligase I gene
M Gariboldi1, A Montecucco, A Columbano
1Division of Experimental Oncology A, Istituto Nazionale Tumori, Milan, Italy.
Molecular Carcinogenesis
|October 1, 1995
Abstract:
We mapped the murine DNA ligase I gene (Lig1) in the mouse genome by using a mapping panel from an interspecific cross. Lig1 mapped to a centromeric part of chromosome 7, a region homologous to human chromosome 19q, where the human homologue LIG1 was localized. In addition, Lig1 expression was analyzed during the course of mouse liver-cell regeneration induced by partial hepatectomy, necrogenic doses of carbon tetrachloride, or the mitogen 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene. The results demonstrate that Lig1 is expressed in the liver during active cell proliferation.