Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

4-(Acetylamino)-3-hydroxy-5-nitrobenzoic acid

M J Jedrzejas1, M Luo, S Singh

  • 1Department of Microbiology, University of Alabama at Birmingham 35294, USA.

Acta Crystallographica. Section C, Crystal Structure Communications
|September 15, 1995
PubMed
Summary

This study details the crystal structure of 4-(acetylamino)-3-hydroxy-5-nitrobenzoic acid, a designed influenza virus neuraminidase inhibitor. The molecule forms hydrogen-bonded dimers, revealing specific dihedral angles and stabilizing intermolecular interactions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Diagnostic value of serum Mac-2 binding protein for the severity of schistosomiasis-induced liver fibrosis].

Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control·2026
Same author

A comparative study of vessel length measurements in branches of eight subtropical woody species based on three methods.

Plant biology (Stuttgart, Germany)·2026
Same author

First Evidence of Solar Neutrino Interactions on ^{13}C.

Physical review letters·2026
Same author

[Epidemiological characteristics and trends of indigenous dengue fever cases in the elderly in Guangdong Province, 2015-2023].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2025
Same author

[Effect and mechanism of astaxanthin on the aging of high glucose-treated human skin fibroblasts].

Zhonghua shao shang yu chuang mian xiu fu za zhi·2025
Same author

Analysis of copy number variations and selection signatures using whole-genome sequencing data from 16 Chinese duck breeds.

British poultry science·2025

Area of Science:

  • Biochemistry
  • Crystallography
  • Virology

Background:

  • Influenza virus neuraminidase is a key target for antiviral drugs.
  • Designing effective inhibitors requires understanding molecular structure and interactions.
  • 4-(acetylamino)-3-hydroxy-5-nitrobenzoic acid is a potential neuraminidase inhibitor.

Purpose of the Study:

  • To determine the crystal structure of 4-(acetylamino)-3-hydroxy-5-nitrobenzoic acid.
  • To analyze the molecular conformation and intermolecular interactions of the designed inhibitor.
  • To provide structural insights for further drug development against influenza.

Main Methods:

  • X-ray crystallography was used to obtain the crystal structure.
  • Analysis of dihedral angles of substituent groups (carboxyl, nitro, acetylamino) relative to the phenyl ring.

Related Experiment Videos

  • Identification and characterization of intermolecular hydrogen bonding networks.

    • Main Results:

    • The molecule C9H8N2O6 crystallizes as hydrogen-bonded dimers.
    • Specific dihedral angles were measured: carboxyl (5.0°), nitro (45.0°), and acetylamino (37.3°).
    • Intermolecular hydrogen bonding significantly stabilizes the crystal structure.

    Conclusions:

    • The determined crystal structure provides a detailed molecular model of the influenza neuraminidase inhibitor.
    • The observed conformation and hydrogen bonding patterns are crucial for understanding its inhibitory mechanism.
    • This structural information can guide the optimization of 4-(acetylamino)-3-hydroxy-5-nitrobenzoic acid for enhanced antiviral activity.