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De/remineralization from sodium fluoride dentifrices

J S Wefel1, M E Jensen, P T Triolo

  • 1Dows Institute for Dental Research, College of Dentistry, University of Iowa, Iowa City 52242, USA.

American Journal of Dentistry
|August 1, 1995
PubMed
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Sodium fluoride toothpastes promote enamel remineralization, with higher fluoride concentrations yielding greater mineral gain. An enhanced fluoride delivery system performed comparably to a high-concentration fluoride toothpaste.

Area of Science:

  • Dental research
  • Cariology
  • Materials science

Background:

  • Dental caries is a significant public health concern.
  • Fluoride is a key agent in preventing and reversing enamel demineralization.
  • Optimizing fluoride delivery systems is crucial for enhancing anticaries efficacy.

Purpose of the Study:

  • To evaluate the demineralization and remineralization effects of sodium fluoride dentifrices.
  • To assess the dose-response relationship of varying fluoride concentrations.
  • To investigate the efficacy of an enhanced fluoride delivery system.

Main Methods:

  • An in situ single-section crown model system was utilized.
  • Participants underwent supervised toothbrushing twice daily for one month.

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  • Enamel and root lesions were analyzed using polarized light microscopy and microradiography.

    • Main Results:

    • The placebo group exhibited significant mineral loss.
    • Fluoride dentifrices demonstrated dose-dependent enamel mineral gain.
    • An enhanced polyampholyte-NaF system (1100 ppm F-) was as effective as 2800 ppm F- dentifrice.
    • Root lesions showed demineralization across all treatments, with similar trends observed.

    Conclusions:

    • Sodium fluoride dentifrices effectively promote enamel remineralization in a dose-dependent manner.
    • Enhanced fluoride delivery systems can achieve significant remineralization benefits.
    • Further research into optimized fluoride formulations is warranted for caries prevention.