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Effect of manufacturing technology on the dissolution of ampicillin tablets
M González1, P Retaco, M T Pizzorno
1Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Argentina.
Bollettino Chimico Farmaceutico
|September 1, 1995
Abstract:
The effect of the manufacturing technology on the dissolution of ampicillin tablets have been analyzed. Several kinetic parameters were then calculated. The dissolution rate of ampicillin increases in tablets prepared by direct compression or dry granulation, with microcrystalline cellulose and colloidal silicon dioxide. Studies of in vitro bioequivalence of the pharmaceutical products available in the Argentine market were performed. We concluded that not all commercial products are equivalent.