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Related Experiment Videos

FGF signaling and target recognition in the developing Xenopus visual system

S McFarlane1, L McNeill, C E Holt

  • 1Department of Biology, University of California, San Diego, La Jolla 92093, USA.

Neuron
|November 1, 1995
PubMed
Summary

Fibroblast growth factor (FGF) signaling guides Xenopus retinal axons. Reduced FGF in the target tectum causes axons to bypass it, impacting neural development.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Signaling

Background:

  • Growth cones of Xenopus retinal ganglion cells express fibroblast growth factor receptors (FGFRs).
  • Basic fibroblast growth factor (bFGF) stimulates neurite extension in cultured retinal neurons.
  • bFGF is abundant in the developing optic tract but reduced in the optic tectum.

Purpose of the Study:

  • To investigate the role of FGF signaling in axonal guidance in vivo.
  • To determine how bFGF levels in the optic tectum affect retinal axon navigation.

Main Methods:

  • Exogenous application of bFGF to the developing optic pathway in "exposed brain" preparations of Xenopus.
  • Observation of retinal axon navigation through the optic tract and tectal border.

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Main Results:

  • FGF-treated retinal axons navigated the optic tract normally.
  • A majority of axons receiving FGF treatment veered aberrantly at the tectal border, bypassing their target.
  • Diminished bFGF levels in the tectum were suggested to slow axonal growth.

Conclusions:

  • FGF signaling is implicated in target recognition for developing retinal axons.
  • Differential bFGF levels between the optic tract and tectum play a crucial role in axonal guidance and target innervation.