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Fenoverine-induced rhabdomyolysis
P Chariot1, R Ratiney, F Le Maguet
1Department of Toxicology, Université Paris 12, Créteil, France.
Human & Experimental Toxicology
|August 1, 1995
Summary
Fenoverine can cause severe rhabdomyolysis, a serious muscle condition, and left-bundle-branch block. Physicians should avoid prescribing it to patients with liver issues or those on cholesterol-lowering drugs.
Area of Science:
- Pharmacology
- Toxicology
- Cardiology
Background:
- Fenoverine is a spasmolytic agent that functions by inhibiting calcium channel currents.
- Rhabdomyolysis is a condition characterized by the breakdown of muscle tissue.
Observation:
- Two patients presented with fenoverine-induced rhabdomyolysis, with one fatality.
- Both patients experienced a transient left-bundle-branch block during fenoverine treatment.
Findings:
- Pre-existing hepatic dysfunction may lead to fenoverine accumulation.
- Concurrent use of fibrates might predispose patients to fenoverine-induced rhabdomyolysis.
Implications:
- Avoid prescribing fenoverine to patients with hepatopathy or those on cholesterol-lowering agents to reduce muscular complications.
- Physicians must recognize the potential for life-threatening adverse effects from seemingly safe medications.