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Herpes simplex virus infections in the neonate
1Sydney University Department of Paediatrics and Child Health, Children's Hospital, Camperdown, New South Wales, Australia.
Journal of Paediatrics and Child Health
|August 1, 1995
Summary
Neonatal herpes simplex virus (HSV) infections require prompt diagnosis. Early antiviral treatment is crucial for improving outcomes in infants with HSV, especially for localized skin, eye, and mouth infections.
Area of Science:
- Neonatal infections
- Virology
- Pediatric infectious diseases
Background:
- Neonatal herpes simplex virus (HSV) infections pose a significant threat to infant health.
- Understanding the clinical presentation and outcomes is vital for effective management.
Purpose of the Study:
- To review the clinical experience with neonatal HSV infections at Camperdown Children's Hospital from 1960 to 1992.
- To analyze the characteristics, outcomes, and treatment responses of affected neonates.
Main Methods:
- A retrospective review of all confirmed cases of neonatal HSV infection.
- Data collection included maternal history, gestational age, birth weight, clinical signs, and disease classification.
Main Results:
- Fifteen cases of neonatal HSV infection were identified.
- Significant mortality (47%) was observed in generalized infections; survivors often had neurological impairment.
- Disseminated and encephalitis forms had poor prognoses, irrespective of antiviral therapy.
Conclusions:
- A high index of suspicion for neonatal HSV is critical for early diagnosis and intervention.
- Prompt initiation of antiviral treatment, particularly for localized infections, may improve prognosis.