Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Screening for clonal genetic alterations

D Sidransky1

  • 1Johns Hopkins University School of Medicine, Department of Otolaryngology, Head & Neck Surgery, Baltimore, Maryland 21205-2196, USA.

European Journal of Cancer (Oxford, England : 1990)
|July 1, 1995
PubMed
Summary

Cancer progression involves clonal expansion, where one cell divides into identical daughter cells. Genetic changes accumulate, driving cancer development and enabling detection through molecular markers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genome-wide profiling of non-smoking-related lung cancer cells reveals common RB1 rearrangements associated with histopathologic transformation in EGFR-mutant tumors.

Annals of oncology : official journal of the European Society for Medical Oncology·2020
Same author

Patient-derived xenografts effectively capture responses to oncology therapy in a heterogeneous cohort of patients with solid tumors.

Annals of oncology : official journal of the European Society for Medical Oncology·2017
Same author

Patient-derived xenografts as tools in pharmaceutical development.

Clinical pharmacology and therapeutics·2016
Same author

Detection of Merkel cell virus and correlation with histologic presence of Merkel cell carcinoma in sentinel lymph nodes.

British journal of cancer·2012
Same author

Absence of germline prohibitin mutations in early-onset breast-cancer.

International journal of oncology·2011
Same author

NID2 and HOXA9 promoter hypermethylation as biomarkers for prevention and early detection in oral cavity squamous cell carcinoma tissues and saliva.

Cancer prevention research (Philadelphia, Pa.)·2011

Area of Science:

  • Oncology
  • Cancer Biology
  • Genetics

Background:

  • Clonality is a core feature of human cancers, originating from a single cell with a growth advantage.
  • Cancer cells accumulate genetic alterations, leading to daughter cells with enhanced growth capabilities.
  • This clonal evolution is linked to histopathological progression in cancers.

Purpose of the Study:

  • To explore the concept of cancer clonality and its role in tumor development.
  • To highlight the correlation between clonal genetic changes and histopathological progression.
  • To emphasize the utility of identifying genetic markers for neoplastic cell outgrowth.

Main Methods:

  • Review of established principles of cancer clonality.
  • Correlation analysis of genetic changes with histopathological cancer progression.
  • Evaluation of genetic markers for detecting neoplastic cell populations.

Main Results:

  • Cancer development is characterized by clonal expansion and the accumulation of advantageous genetic mutations.
  • A molecular progression model for colorectal cancer is supported by these clonal genetic changes.
  • Genetic markers are effective in identifying clonal outgrowth and detecting primary neoplasms.

Conclusions:

  • Clonality is a fundamental driver of cancer evolution and progression.
  • Understanding clonal genetic changes aids in developing molecular progression models.
  • Genetic markers hold significant potential for early cancer detection.

Related Experiment Videos