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Radiotherapy and hyperthermia

D González González1, J D van Dijk, L E Blank

  • 1Department of Radiotherapy, Academic Medical Centre, University of Amsterdam, The Netherlands.

European Journal of Cancer (Oxford, England : 1990)
|July 1, 1995
PubMed
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Combined radiotherapy and locoregional hyperthermia is a feasible treatment for advanced colorectal cancer, offering palliation in 75% of patients. However, achieving therapeutic temperatures remains a challenge.

Area of Science:

  • Oncology
  • Radiation Oncology
  • Medical Physics

Background:

  • Colorectal cancer recurrence and unresectable cases present treatment challenges.
  • Combined modality treatments are explored to improve outcomes.

Purpose of the Study:

  • To evaluate the feasibility, toxicity, and efficacy of combined radiotherapy and locoregional hyperthermia in patients with unresectable or recurrent colorectal cancer.
  • To assess palliative effects and survival outcomes.

Main Methods:

  • 72 patients received radiotherapy (50 Gy or 32 Gy) combined with locoregional hyperthermia.
  • Hyperthermia sessions aimed for temperatures >= 41°C for 30 minutes, delivered near irradiation.
  • Toxicity, palliation rates, objective remission, and survival were assessed.

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Main Results:

  • Palliation was achieved in 75% of patients (mean duration 12 months), with higher rates correlating with higher radiation doses.
  • Objective remission was observed in 15% of patients.
  • Median survival was 11 months, with 17% alive at 3 years. Common toxicities included pain and discomfort, leading to treatment interruption in 17%.

Conclusions:

  • Thermoradiotherapy is a feasible treatment option for colorectal cancer.
  • While acute and late toxicities are manageable, patient discomfort can hinder treatment.
  • Current hyperthermia equipment often fails to reach optimal therapeutic intratumoral temperatures.