Manual compared with target-controlled infusion of propofol

Area of Science:

• Anesthesiology
• Pharmacology

Background:

• Propofol infusion is a common anesthetic technique.
• Manual and target-controlled infusion (TCI) systems exist for propofol administration.
• Anesthesiologist experience with TCI can influence its adoption.

Purpose of the Study:

• To compare the efficacy and ease of use of target-controlled infusion (TCI) versus manually controlled infusion (MCI) of propofol.
• To evaluate the impact of TCI on anesthetic induction, maintenance, and recovery.
• To assess anesthesiologist preference for TCI versus MCI.

Main Methods:

• A study involving 160 ASA I-II patients.
• Anesthesia administered using propofol via either TCI or MCI systems.
• Eight consultant anesthesiologists with limited TCI experience participated.
• Standard premedication and co-analgesics were administered.

Main Results:

• TCI led to more rapid anesthetic induction and earlier laryngeal mask airway insertion.
• Significantly less patient movement was observed with TCI during surgery.
• Higher propofol doses were used with TCI, with increased end-tidal carbon dioxide during maintenance.
• Recovery times were not significantly prolonged with TCI.
• Hemodynamic variables remained similar between groups.

Conclusions:

• Target-controlled infusion (TCI) of propofol facilitates faster induction and improved control of surgical movement.
• Anesthesiologists, even with limited prior experience, found TCI easier to use and preferred it over manual control.
• TCI represents a valuable and preferred method for propofol administration in anesthesia.