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Inhibition of herpes simplex virus replication by antisense oligo-2'-O-methylribonucleoside methylphosphonates

J M Kean1, S A Kipp, P S Miller

  • 1Department of Biochemistry, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA.

Biochemistry
|November 14, 1995
PubMed
Summary

Modified antisense oligonucleotides show promise for inhibiting herpes simplex virus type 1 (HSV-1) replication. Oligo-2'-O-methylribonucleoside methylphosphonates demonstrated higher binding affinity and potent antiviral activity compared to deoxyribonucleoside analogs.

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