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Biodegradable polymers for protein and peptide drug delivery
1Department of Drug Delivery and Formulation, Immunex Corporation, Seattle, Washington 98101, USA.
Bioconjugate Chemistry
|July 1, 1995
Summary
Degradable polymeric delivery systems offer advanced protein and peptide drug administration. While challenges exist, successful products highlight their significant therapeutic advantages and future potential.
Area of Science:
- Biomaterials Science
- Pharmaceutical Sciences
- Drug Delivery
Background:
- Protein and peptide pharmaceuticals require specialized delivery systems due to administration challenges.
- Degradable polymers offer potential for controlled release of these biologics.
- Current systems include monolithic devices and protein-polymer conjugates.
Purpose of the Study:
- To review degradable polymeric delivery systems for protein and peptide pharmaceuticals.
- To identify challenges and successes in the development of these systems.
- To anticipate future demands for advanced drug delivery.
Main Methods:
- Literature review of scientific reports on degradable polymeric delivery systems.
- Analysis of monolithic devices and protein-polymer conjugates.
- Evaluation of preclinical data and market-approved products.
Main Results:
- Degradable polymeric systems face challenges in protein stability and release kinetics.
- Numerous preclinical studies show promising results.
- Few systems have reached the market, but those that have are highly successful.
Conclusions:
- Successful market products demonstrate the significant benefits of these advanced delivery systems.
- Continued advances in biotechnology will increase the need for novel protein and peptide delivery methods.
- Controlled or site-specific delivery systems are expected to see increased demand.