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Related Experiment Videos

Hemoglobin variants recently detected in Austria

W J Schnedl1, E C Reisinger, R W Lipp

  • 1Department of Internal Medicine, Karl Franzens University, Graz, Austria.

Annals of Hematology
|October 1, 1995
PubMed
Summary

Routine measurement of glycated hemoglobin (HbA1c) helps manage diabetes. HPLC analysis can reveal silent hemoglobin variants like Hb Graz, impacting HbA1c readings in diabetic patients.

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Area of Science:

  • Clinical Chemistry
  • Hematology
  • Diabetology

Background:

  • Glycated hemoglobin (HbA1c) is crucial for monitoring diabetes management.
  • HbA1c reflects average blood glucose over the preceding 3 months.
  • Certain hemoglobin variants can interfere with standard HbA1c assays.

Purpose of the Study:

  • To review the detection of silent hemoglobin variants during HbA1c measurement.
  • To highlight specific variants like Hb Graz, Hb Sherwood Forest, and Hb Okayama.
  • To discuss the implications of these variants in diabetic patient management.

Main Methods:

  • High-performance liquid chromatography (HPLC) was utilized for HbA1c determination.
  • Analysis focused on identifying abnormal HbA1c values in diabetic patients.

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  • Case studies involving specific hemoglobin variants were reviewed.

    • Main Results:

    • HPLC detected elevated HbA1c values in some diabetic patients due to hemoglobin variants.
    • Hb Graz was identified as one such variant impacting HbA1c measurements.
    • Other silent hemoglobin variants, including Hb Sherwood Forest and Hb Okayama, were also found.

    Conclusions:

    • Silent hemoglobin variants can lead to inaccurate HbA1c results.
    • HPLC is effective in identifying these variants during routine diabetes monitoring.
    • Awareness of these variants is essential for accurate diabetes management.