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Candidal brain abscess associated with vascular invasion: a devastating complication of vascular catheter-related
S J Burgert1, D C Classen, J P Burke
1Department of Clinical Epidemiology, LDS Hospital, Salt Lake City, Utah 84143, USA.
Abstract:
We describe a patient who developed Candida albicans brain abscess associated with prominent vascular invasion following an episode of central venous catheter-related fungemia. The increasing population of immunosuppressed patients and the frequent use of broad-spectrum antimicrobials, corticosteroids, chemotherapeutics, organ transplantation, and prolonged supportive measures are responsible for an increasing incidence of candidal infections. Brain abscess is a rare complication of candidemia but may be expected to become more common as venous catheter-related fungemia is encountered more frequently.
Insights
A rare Candida albicans brain abscess developed in a patient with a central venous catheter. This case highlights the growing risk of fungal infections in immunocompromised patients, particularly with invasive devices.
Area of Science:
- Mycology
- Infectious Diseases
- Neurology
Background:
- Candidal infections are increasing due to a rise in immunocompromised patients.
- Immunosuppression is often linked to treatments like broad-spectrum antimicrobials, corticosteroids, and chemotherapy, as well as organ transplantation and extensive supportive care.
Observation:
- A patient developed a Candida albicans brain abscess.
- This complication occurred after an episode of fungemia (fungal infection in the bloodstream) related to a central venous catheter.
Findings:
- The brain abscess showed significant invasion of blood vessels.
- Central venous catheter-related fungemia is a known risk factor for invasive candidiasis.
Implications:
- Brain abscess is a rare but serious complication of candidemia.
- The incidence of such fungal brain infections may rise with the increasing prevalence of central venous catheter use and associated fungemia.