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Experimental immunity against trypanosomiasis in sheep

C Powell, L T Mathaba

    Medical Journal of Zambia
    |June 1, 1978
    PubMed
    Summary
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    Sheep inoculated with Trypanosoma rhodesiense fraction 3 showed no parasitemia and high IgG levels when challenged with T. vivax. This suggests a potential protective effect against trypanosomiasis.

    Area of Science:

    • Veterinary immunology
    • Parasitology
    • Animal health

    Background:

    • Trypanosomiasis is a significant disease affecting livestock.
    • Trypanosoma vivax and Trypanosoma rhodesiense are causative agents of significant veterinary concern.
    • Understanding immune responses to trypanosome antigens is crucial for developing control strategies.

    Purpose of the Study:

    • To investigate the immune response in sheep inoculated with Trypanosoma rhodesiense components.
    • To assess the protective effect of T. rhodesiense fraction 3 against subsequent T. vivax challenge.

    Main Methods:

    • Three groups of male sheep were utilized.
    • Group 1: Control (no inoculation).
    • Group 2: Inoculated with T. rhodesiense homogenate.

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  • Group 3: Inoculated with T. rhodesiense "fraction 3".
  • All groups were subsequently challenged with 1 x 10(6) T. vivax.

    • Main Results:

    • Sheep inoculated with T. rhodesiense fraction 3 exhibited elevated IgG levels.
    • Parasitemia was notably absent in the group that received T. rhodesiense fraction 3.
    • The control and T. rhodesiense homogenate groups' responses require further detailed reporting.

    Conclusions:

    • Inoculation with T. rhodesiense fraction 3 may confer protection against T. vivax challenge in sheep.
    • High IgG levels correlate with the absence of parasitemia, indicating a potential immune mechanism.
    • Further research is warranted to elucidate the specific components within "fraction 3" responsible for this effect.