Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

In-vitro models of B-lineage commitment

B L Kee1, C J Paige

  • 1Wellesley Hospital Research Institute, University of Toronto, Canada.

Seminars in Immunology
|June 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Developing and implementing a fluoride varnish programme for young children in Bradford, UK.

Community dental health·2014
Same author

Diminished pheromone-induced sexual behavior in neurokinin-1 receptor deficient (TACR1(-/-)) mice.

Genes, brain, and behavior·2012
Same author

Helix-loop-helix proteins in lymphocyte lineage determination.

Current topics in microbiology and immunology·2006
Same author

Stromal cells attract B-cell progenitors to promote B-cell-B-cell contact and maturation.

Scandinavian journal of immunology·2005
Same author

Pre-B cell receptor signaling mediates selective response to IL-7 at the pro-B to pre-B cell transition via an ERK/MAP kinase-dependent pathway.

Immunity·2001
Same author

The role of homotypic interactions in the differentiation of B cell precursors.

European journal of immunology·2001
Same journal

Myeloid cells as sources and targets of IL-1 family cytokines in cancer.

Seminars in immunology·2026
Same journal

Interleukin-1-mediated inflammatory memory: Protective training or maladaptive tumor imprinting?

Seminars in immunology·2026
Same journal

Chronic stress at the crossroads: Decoding the HPA-SAM-immune-gut axis in inflammatory bowel disease pathogenesis and therapeutics.

Seminars in immunology·2026
Same journal

Protein tyrosine kinases in dendritic cell-mediated anti-cancer immunity.

Seminars in immunology·2026
Same journal

The immune system in Latin America and the Caribbean: Insights into diseases and diversity from local perspectives.

Seminars in immunology·2026
Same journal

Introduction to the special issue: T<sub>H</sub>9 cells in diseases.

Seminars in immunology·2026
See all related articles

This review explores B lymphocyte development, detailing the pathway from multipotent progenitors to committed B cells. It discusses models and potential mediators of B-lineage commitment, a key step in immune cell differentiation.

Area of Science:

  • Immunology and Developmental Biology
  • Hematopoiesis and Lymphopoiesis

Background:

  • B lymphocyte development involves differentiation from multipotent progenitors with progressive lineage restriction.
  • Critical components of B cell differentiation are known, but the genetic basis for lineage determination is unresolved.

Purpose of the Study:

  • To present a model of B-lineage progression from multipotent progenitors to committed B-cell progenitors.
  • To discuss potential mediators involved in the B-cell lineage commitment process.

Main Methods:

  • Review of existing literature on B lymphocyte development and differentiation pathways.
  • Discussion of recently established in-vitro assays supporting B cell progenitor development.

Main Results:

Related Experiment Videos

  • A model for B-lineage progression is presented, outlining key stages from progenitor to committed cell.
  • In-vitro assays provide a novel system for studying and manipulating B lineage commitment.

    • Conclusions:

    • Understanding B-lineage commitment is crucial for comprehending immune system development.
    • Further research into the mediators of commitment can elucidate genetic control of lymphocyte differentiation.