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Stability of ifosfamide in solutions for multiday infusion by external pump
L Leone1, A Comandone, C Oliva
1Laboratorio Analisi, Ospedale Regina Margherita, Torino, Italy.
Anti-Cancer Drugs
|August 1, 1995
Summary
Ifosfamide stability was assessed for 7-day infusions. Results show no significant loss of drug activity, supporting its safe use in continuous delivery for cancer treatment.
Area of Science:
- Oncology
- Pharmacology
- Drug Stability
Background:
- Ifosfamide is a crucial chemotherapeutic agent.
- Drug toxicity and metabolite activation are key concerns.
- Continuous infusion may optimize ifosfamide therapy.
Purpose of the Study:
- To evaluate the stability of ifosfamide in solution.
- To determine the feasibility of 7-day continuous infusion.
- To assess if co-administration with mesna affects ifosfamide stability.
Main Methods:
- High-Performance Liquid Chromatography (HPLC) was used for analysis.
- Ifosfamide stability was tested in Ringer lactate buffer.
- Samples were analyzed at 37°C over a 7-day period.
Main Results:
- Ifosfamide demonstrated excellent stability over 7 days.
- The total decay in ifosfamide activity was less than 3.2%.
- Co-administration with mesna did not compromise ifosfamide stability.
Conclusions:
- Ifosfamide is stable for 7-day continuous infusion.
- This delivery method is feasible and safe.
- Reduced toxicity and increased active metabolites are potential benefits.