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Published on: November 16, 2012
The gtcRS operon coding for two-component system regulatory proteins is located adjacent to the grs operon of
1Philipps Universität Marburg, Germany.
Abstract:
We identified, cloned and sequenced an operon comprising of two genes gtcR and gtcS located adjacent to the grs operon of Bacillus brevis, which encodes the multienzymes involved in the biosynthesis of the peptide antibiotic gramicidin S. The transcription initiation site of the gtcRS operon was determined in Bacillus brevis and Bacillus subtilis. The encoded proteins GtcR and GtcS were identified as members of the two-component system family of signal transducing proteins.
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