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Mania in Alzheimer's disease
C G Lyketsos1, K Corazzini, C Steele
1Department of Psychiatry, Johns Hopkins University and Hospital, Baltimore, MD, USA.
The Journal of Neuropsychiatry and Clinical Neurosciences
|January 1, 1995
Abstract:
A chart review of 134 patients with Alzheimer's disease (AD) showed a 2.2% prevalence of mania, lower than previously cited. Of 3 patients with mania, 2 had a history of mania before the onset of AD. Prevalence rates and the role of Alzheimer's disease in the development of mania are discussed.
Insights
This study found a 2.2% prevalence of mania in Alzheimer's disease (AD) patients, which is lower than previously reported. Most cases of mania occurred in patients with a pre-existing history of mania.
Area of Science:
- Neurology
- Psychiatry
Background:
- Alzheimer's disease (AD) is a progressive neurodegenerative disorder.
- The relationship between AD and psychiatric comorbidities like mania requires further investigation.
Observation:
- A chart review was conducted on 134 patients diagnosed with Alzheimer's disease.
- The study specifically examined the prevalence of manic episodes within this cohort.
Findings:
- A prevalence of 2.2% for mania was observed in patients with Alzheimer's disease.
- Of the three patients who experienced mania, two had a prior history of manic episodes before AD onset.
Implications:
- The findings suggest that Alzheimer's disease may not be a primary driver for the development of mania.
- Further research is needed to elucidate the complex interplay between neurodegeneration and mood disorders.