Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental immunity against trypanosomiasis

C N Powell

    Experientia
    |November 15, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Fraction 3 of Trypanosoma rhodesiense demonstrated significant immunoprotection in rats against T. brucei challenge. Doses of 500 micrograms achieved 100% protection, while higher doses also showed efficacy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Partial protection against natural trypanosomiasis after vaccination with a flagellar pocket antigen from Trypanosoma brucei rhodesiense.

    Vaccine·1995
    Same author

    Determination of IgG antibodies produced by the kinetoplast fraction antigens of Trypanosoma rhodesiense, T. vivax and T. brucei by enzyme linked immunosorbent assay.

    Medical journal of Zambia·1977
    Same journal

    On the influence of aneurine on the formation of nitrogenic bacterial nodites.

    Experientia·2010
    Same journal

    Around the biochemical activities of the flavobacterium.

    Experientia·2010
    Same journal

    Electron microscopic investigations on cellulose fibers after treatment with ultrasound.

    Experientia·2010
    Same journal

    Reviving scientific life in Hungary.

    Experientia·2010
    Same journal

    A new method for the production of deoxy sugars.

    Experientia·2010
    Same journal

    About the aneine content of the irritated and irritated frog nerves after poisoning with mono-iodoacetic acid.

    Experientia·2010
    See all related articles

    Area of Science:

    • Immunology
    • Parasitology
    • Biochemistry

    Background:

    • Trypanosoma rhodesiense is a protozoan parasite that causes African trypanosomiasis.
    • Developing effective immunoprotective strategies against trypanosomiasis is crucial for public health.

    Purpose of the Study:

    • To evaluate the immunoprotective potential of fraction 3 from Trypanosoma rhodesiense against Trypanosoma brucei.
    • To determine the efficacy of different dosages of fraction 3 in conferring protection.

    Main Methods:

    • Female rats were divided into groups and immunized with varying doses of Trypanosoma rhodesiense fraction 3.
    • Immunoprotection was assessed by challenging the rats with a controlled dose of Trypanosoma brucei.
    • A short-term inoculation immune response was also evaluated.

    Related Experiment Videos

    Main Results:

    • A dose of 500 micrograms of fraction 3 resulted in 100% immunoprotection.
    • Doses of 1000 and 1500 micrograms provided 66% immunoprotection.
    • In a separate short-term study, 750 micrograms of fraction 3 yielded 70% immunoprotection.

    Conclusions:

    • Fraction 3 of Trypanosoma rhodesiense exhibits dose-dependent immunoprotective properties against Trypanosoma brucei.
    • This fraction holds promise as a potential component for developing vaccines or therapies against African trypanosomiasis.