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Acute hemolysis during cyclosporine therapy successfully treated with vitamin E
E Azuma1, M Hirayama, T Nakano
1Department of Pediatrics and Clinical Immunology, Mie University School of Medicine, Japan.
Bone Marrow Transplantation
|August 1, 1995
Abstract:
The immunosuppressant cyclosporine induces acute hemolysis (hemolytic uremic syndrome) in some patients after transplantation, possibly because of its effects on the vascular endothelium. We report a case of Coombs-negative, non-immune severe hemolytic anemia during cyclosporine therapy after allogeneic bone marrow transplantation for severe aplastic anemia. Uremia was not observed. Vitamin E was effective in treating the intravascular hemolysis.