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Updated: Aug 4, 2026

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
Published on: October 10, 2016
Combined polymerized chiral micelle and gamma-cyclodextrin for chiral separation in capillary electrophoresis
1Department of Chemistry, Louisiana State University, Baton Rouge 70803, USA.
Abstract:
A combination of a polymerized chiral micelle, poly(sodium N-undecylenyl-D-valinate) [poly(D-SUV)] and gamma-cyclodextrin (gamma-CD) is used for the first time for chiral separation in capillary electrophoresis. A simple theory is presented to rationalize the synergistic effect of the enantioselectivity obtained by use of poly(D-SUV) and gamma-CD in combination. A mixture of four enantiomeric pairs is successfully resolved by use of this combination. The resolutions of the enantiomers using this approach are far superior to those obtained by use of either poly(D-SUV) or gamma-CD alone. In addition, the effects of the antipode (L-SUV), gamma-CD concentration, buffer concentration, organic solvents, and urea concentration on the resolution are also examined.
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