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Comparison of high-performance liquid chromatography and capillary zone electrophoresis in penciclovir biodegradation
L C Hsu1, D J Constable, D R Orvos
1Environmental Research Laboratory, SmithKline Beecham Corporation, King of Prussia, PA 19406, USA.
Abstract:
High-performance liquid chromatography (HPLC) and capillary zone electrophoresis (CZE) were used in biodegradation kinetic studies. This paper describes a rapid penciclovir separation using CZE with detection limits comparable to HPLC. The ionic-strength mediated stacking technique was employed while good resolution was maintained. With a shorter analysis time, comparable detection limits and no organic solvent consumption, CZE is a better method for penciclovir biodegradation studies than conventional reversed-phase HPLC (RP-HPLC).