Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Myoclonus

H Shibasaki1

  • 1Department of Brain Pathophysiology, Kyoto University School of Medicine, Japan.

Current Opinion in Neurology
|August 1, 1995
PubMed
Summary
This summary is machine-generated.

This study explores cortical reflex myoclonus, proposing a new concept of negative myoclonus. It highlights its presence in various neurodegenerative disorders and discusses unique features in corticobasal degeneration.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Timing of initiation of adjuvant chemotherapy for gastric cancer: A case-matched comparison study of laparoscopic vs. open surgery.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2017
Same author

Effect of low-temperature degradation on the mechanical and microstructural properties of tooth-colored 3Y-TZP ceramics.

Journal of the mechanical behavior of biomedical materials·2015
Same author

Concurrence of non-myasthenic symptoms with myasthenia gravis.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2007
Same author

Cognitive slowing in Parkinson disease is accompanied by hypofunctioning of the striatum.

Neurology·2007
Same author

Neurophysiological classification of myoclonus.

Neurophysiologie clinique = Clinical neurophysiology·2007
Same author

Ictal monoparesis associated with lesions in the primary somatosensory area.

Neurology·2005

Area of Science:

  • Neuroscience
  • Epileptology
  • Clinical Electrophysiology

Background:

  • Genetic studies suggest homogeneity between Baltic-type and Mediterranean-type progressive myoclonic epilepsy.
  • Cortical reflex myoclonus is characterized by giant evoked responses.
  • Myoclonus appears in diverse neurodegenerative and metabolic conditions.

Purpose of the Study:

  • To elucidate the mechanism of giant evoked responses in cortical reflex myoclonus using magnetoencephalography.
  • To propose a new concept of negative myoclonus mediated by cortical reflex mechanisms.
  • To analyze the clinical and electrophysiological features of myoclonus in various disorders, particularly corticobasal degeneration.

Main Methods:

  • Magnetoencephalography (MEG) was employed to investigate evoked responses.

Related Experiment Videos

  • Clinical features and electrophysiological data of patients with myoclonus were analyzed.
  • Comparison of myoclonus characteristics across different neurological disorders.

    • Main Results:

    • Magnetoencephalography provided insights into the mechanism of giant evoked responses.
    • A novel concept of negative myoclonus, mediated by cortical reflex mechanisms, was proposed.
    • Cortical myoclonus was identified in conditions including dementia, olivopontocerebellar atrophy, and myoclonus epilepsy.
    • Myoclonus in corticobasal degeneration exhibited features of cortical reflex myoclonus but with shorter latency.

    Conclusions:

    • Cortical reflex mechanisms play a significant role in myoclonus.
    • Negative myoclonus represents a distinct pathophysiological entity.
    • Understanding myoclonus in neurodegenerative diseases is crucial for diagnosis and management.
    • Corticobasal degeneration presents with unique electrophysiological characteristics of myoclonus.